Kayla Barnes-Lentz（35 岁）把自己当作「一人实验室」，在长寿产业快速扩张之际主张女性需要不同的证据基础。UK 的 Longevity.Technology 估计，2024 年全球长寿领域投资达到 84.9 亿美元（$8.49 billion），较前一年增加逾 2 倍；但基础老化生物学与主流长寿方案多建立在男性资料上，像 Bryan Johnson、Andrew Huberman 与 Peter Attia 的作法也多承袭此脉络，因此她形容女性「被排除在对话之外」。
她赴旧金山参加首届 Livelong Women’s Health Summit，面向 2,000 名付费与会者；现场票价最高达 1,995 美元（$1,995）。女性平均寿命较长，但不健康年数也较多，且在骨质流失与失智风险上升等方面承担更大负担；然而美国 National Institutes of Health 直到 1993 年才要求女性纳入人体临床试验，并于 2016 年才要求将「性别」作为生物变项加以考量。
Barnes-Lentz 在 2020 年于克里夫兰开设长寿诊所，并以自身测试臭氧、胜肽、治疗性血浆置换等介入；她指出热量限制在男性身上常见正向经验，但她出现甲状腺指标失衡与月经不规则。她引用 2023 年研究：以小鼠为主的热量限制研究高度偏向雄性，且在年轻雌性小鼠与年轻女性中代谢效益减弱或消失。她如今以较低风险的生活型态为核心（例如约 15:00 用晚餐、20:30 就寝），其 podcast 约 100,000 订阅者与 Instagram 逾 600,000 追踪者；而在舞台上（11:40）她强调周期中黄体期需要更多睡眠，主持人亦提到禁食后掉了约 1/4 的头发，凸显「男性化」方案在女性身上的代价。
Kayla Barnes-Lentz (35) treats her body as a one-person laboratory and argues that women need different evidence as the longevity industry scales. UK-based Longevity.Technology estimates global longevity investment reached $8.49 billion in 2024, more than doubling versus the prior year; yet foundational aging biology and many headline protocols are built on male bodies, echoed by prominent evangelists such as Bryan Johnson, Andrew Huberman, and Peter Attia, leaving women “out of the conversation.”
In San Francisco she speaks at the first Livelong Women’s Health Summit to 2,000 paying attendees, with at-the-door tickets topping out at $1,995. Women tend to live longer than men but spend more years in poor health and face higher risks like bone loss and dementia; nonetheless, the US National Institutes of Health required inclusion of women in human clinical trials only in 1993, and required sex be treated as a biological variable only in 2016.
Barnes-Lentz opened a longevity clinic in Cleveland in 2020 and self-tested interventions (ozone therapy, peptides, therapeutic plasma exchange), concluding that caloric restriction often praised in male-centered research backfired for her via disrupted thyroid markers and irregular periods. She points to a 2023 paper finding caloric-restriction mouse studies skew heavily male and that metabolic benefits are weakened or absent in younger female mice and similarly in younger women. She now centers lower-risk routines (e.g., dinner around 3 p.m., bed at 8:30 p.m.), has ~100,000 podcast subscribers and 600,000+ Instagram followers, and onstage (11:40 a.m.) highlights cycle-linked sleep needs; the moderator reports fasting led to losing about one quarter of her hair, underscoring female-specific tradeoffs.