过去科学界普遍认为致幻剂会使大脑常规组织松散并增加神经信号的混乱度，但发表于《自然》期刊的一项大规模神经影像研究发现，在裸盖菇素（psilocybin）引起的表面混乱下存在著隐藏的秩序。研究人员利用 fMRI 和 EEG 追踪了 62 名受试者在冥想、听音乐或看电影时的 332 个大脑区域变化，并透过人工智慧识别出大脑对当下体验的神经反应变得更加清晰与鲜明。

研究结果显示，受试者的裸盖菇素体验越强烈，其神经活动模式就越明确，现实体验在大脑中留下的印记反而更加深刻。这种生物学测量结果与受试者的主观感受高度吻合，大脑活动模式最清晰的人往往报告了更强烈的沉浸感，以及与周围世界融为一体的合一感，自我与环境之间的界限变得模糊。

这项研究修正了裸盖菇素只会让大脑陷入「混乱」的传统观点，为致幻体验中的「天人合一」感提供了生物学解释。研究团队强调，情境与环境并非仅仅是致幻体验的背景，这一发现对新兴的迷幻药辅助心理治疗具有重要意义，进一步证实了治疗期间的环境设置与患者体验对疗效至关重要。

Scientists traditionally believed that psychedelics loosen the brain's normal organization and increase neural entropy, but a major neuroimaging study published in Nature reveals a hidden order beneath the apparent chaos induced by psilocybin. By tracking 332 brain regions in 62 participants during meditation, music listening, or movie watching via fMRI and EEG, researchers used AI to discover that neurological responses to present experiences actually became more distinct.

The findings demonstrated that a more intense psilocybin experience corresponded to clearer neural patterns, showing that reality leaves a stronger imprint rather than getting lost in brain chaos. These biological signals aligned with participants' subjective reports, as those with the most defined neural patterns experienced greater immersion and a profound sense of unity with their surroundings, where boundaries between the self and the environment blurred.

This study refines the notion that psilocybin simply renders the brain chaotic, offering a biological explanation for the feelings of oneness commonly reported during psychedelic trips. The researchers emphasize that context and setting are integral components rather than mere background, reinforcing the clinical importance of environment and curated experiences in emerging psychedelic-assisted therapies.