洛杉矶在全美自行车网路中被评为第 1,136 名，且今年已有至少 12 名骑士死亡，使其成为高风险城市。Waymo 的安全数据显示其自动驾驶车在营运城市中造成行人受伤的机率比人类驾驶低 92%，对自行车骑士造成受伤的机率低 78%，促使部分自行车倡议者改变立场。全美多城（含休士顿、多家业者如 Waymo、Nuro、Cruise）持续扩大测试，使一些团体主张务实面对能快速改善安全的技术。研究显示骑士对 AV 的信任提升幅度有限，最大决定因素不是技术，而是基础设施配置。

Waymo、Zoox 等企业积极与自行车倡议组织互动，参与会议、提供赞助，并协作推动联邦法规要求 AV 能可靠侦测自行车与行人。代表性组织（如 League of American Bicyclists）受邀前往洛杉矶拍摄宣传影片并确认 AV 周边骑乘的主观安全感。研究指出接触 AV 可带来「些微」舒适度上升，但骑士仍怀念人类驾驶的微互动提示。整体上，自行车安全感仍取决于安全、自主的路权配置，而非 AV 能力本身。

旧金山的经验显示 AV 扩张也可能加深汽车依赖，例如市政府允许 Waymo、Uber、Lyft 进入原规划禁止私人车的 Market Street。AV 接送行为也引发冲突，包括占用自行车道与导致受伤的法律诉讼。奥斯汀等城市同样担忧 AV 导致步行、骑乘、运输改革受挫。倡议者保持警戒，但部分人士期望 AV 业者支持以街道安全为核心的基础设施政策，使双方利益一致。

Los Angeles ranks 1,136th nationally for bike networks, with at least 12 cyclist deaths this year, underscoring high vulnerability. Waymo’s safety data indicates its vehicles are 92 percent less likely than human drivers to cause pedestrian injuries and 78 percent less likely to injure cyclists, shifting some advocates’ attitudes. Multiple US cities, including Houston, have expanded AV testing with firms such as Waymo, Nuro, and Cruise, prompting calls for pragmatic solutions that deliver rapid safety gains. Research shows rider trust in AVs increases only marginally and is driven primarily by infrastructure conditions rather than vehicle technology.

Companies like Waymo and Zoox actively engage cycling groups, joining meetings, sponsoring events, and supporting federal rules requiring AVs to detect cyclists and pedestrians. Organizations such as the League of American Bicyclists collaborated on promotional work and reported subjective safety when biking near AVs. Studies find limited trust gains and note that riders miss human signaling cues. Ultimately, perceived safety depends chiefly on protected, well-designed infrastructure rather than autonomous driving performance.

San Francisco illustrates how AV expansion can reinforce auto dependency, including allowing Waymo, Uber, and Lyft onto a corridor once slated for private-vehicle restrictions. AV pickups and drop-offs in bike lanes have caused conflicts and injuries, even prompting lawsuits. Austin shows similar concerns that AV growth may slow momentum for transit, walking, and biking. Advocates remain cautious but hope AV firms will support infrastructure policies that advance safer streets and align with network reliability needs.