研究显示，白皙皮肤中约80%的老化是由紫外线照射引起的，而黑色素较多的深色皮肤则具有一定程度的保护作用。尽管多数去皱产品的效果声称缺乏严谨的临床证据，但有少数成分具备坚实的科学支持。

在20世纪80年代中期发现能减少皱纹的维A酸（tretinoin）是科学依据最强的抗衰老成分，它能增厚表皮并促进胶原蛋白产生。非处方的温和视黄醇类产品即使在低至0.04%的浓度下也能发挥作用，但需要逐渐建立耐受以避免皮肤刺激。

此外，维生素C等抗氧化剂和多肽虽然也能改善皮肤状态，但前者易失活且后者多依赖公司资助的研究。皮肤科医生建议，这些护肤方案需要坚持使用数月才能判定效果，但最有效的防衰老手段依然是防晒。

Studies show that around 80% of ageing in white skin is caused by ultraviolet exposure, while darker skin with more melanin receives a degree of protection. Although most anti-wrinkle claims lack rigorous clinical evidence, a handful of ingredients do have solid scientific backing.

Tretinoin, found to reduce wrinkles in the mid-1980s, has the strongest scientific support by thickening the epidermis and stimulating collagen production. Milder over-the-counter retinoids can be effective at concentrations as low as 0.04%, but users should start slowly to avoid skin irritation.

Additionally, while antioxidants like vitamin C and peptides can improve skin, the former is unstable and the latter often relies on company-funded research. Dermatologists recommend maintaining a regimen for several months to judge results, though sun protection remains the most effective preventive measure.

Source: The chemicals that reduce wrinkles

Subtitle: Vitamins, applied properly, can partially reverse the effects of ageing

Dateline: 6月 11, 2026 05:16 上午